‘Sure, that is definitely about correct. I seek for a physical knowledge of Organic methods in a very base-up way. I believe you could possibly distinguish three lines of exploration in my team in the meanwhile. The main issues chromosome framework: How does one get a metre-extended DNA polymer folded and organised in this kind of microscopic mobile? We have designed visualisation procedures that allow us to study how, by way of example, SMC proteins loop DNA (online video on Youtube) in order to Develop up chromosomes.
You frequently get involved in conversations about science and faith. You have also published many books on the subject. Don’t you think that eventually We'll know all the things and that God’s job is going to be over?
‘It was just a matter of buying up a e book on cell biology and starting to browse. I'd come from a world of extremely-large vacuums, cryostats and quantum phenomena, and now I was Doing the job at place temperature with molecular biology kits.
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
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SMC complexes can go Actual physical roadblocks larger than their ring measurement, indicating a nontopological mechanism for DNA loop extrusion
Length control of person carbon nanotubes by nanostructuring With all the scanning tunneling microscope
He also identified time to jot down many books, send out Nearly forty thousand tweets and direct a successful investigation team at Delft University of Technological know-how. ‘It doesn’t come to feel like work’, he states. ‘I’m just terribly curious.’
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There was a single dilemma while — we didn't notice any measurable electrical conduction from The one polymer molecules. We concluded that at The one-molecule amount, conducting polymers were actually not these kinds of wonderful conductors, which was somewhat disappointing. We So broadened our view to test to find much more promising molecules.
Example (four) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is demonstrated in gray, the rim in the pore is highlighted in red, and a 3D rendering of your movement on the DNA rod is displayed.
Later on we spoke once more briefly mainly because Dekker felt that our dialogue of his faith rapidly grew to become purely philosophical, While In addition it concretely helps him in his perform.
Allow’s 1st glance back again at this time whenever you ceesdekker.net decided to shift your target from superconductivity and nanotubes to biology at the end of the nineties.
2004, discovery of new physics in translocation of DNA through nanopores; initially experimental examine of ions conduction in nanofluidic channels; initial electrochemistry with individual one-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; to start with electrical docking of microtubules on kinesin-coated nanostructures; 1st biophysics characterization from the mechanical Attributes of double-stranded RNA; and 1st single-molecule analyze of DNA translocation by a restriction-modification enzyme.