Nanotechnology offers a range of options to lead to biology. Below I'll existing illustrations where by nanofabrication – a chance to make confined buildings with Proportions at will – is used to examine the biophysics of single molecules and cells. I will existing some examples from our lab:
Human Rad51 filaments on double- and one-stranded DNA: correlating typical and irregular sorts with recombination function.
[Laughs] ‘It absolutely was unquestionably an awesome hazard! At enough time, I used to be properly mindful that it could go Improper and that I could grow to be much less successful, but I just ignored that. Curiosity has normally been my strongest driving drive. And by chance all of it worked out.’
2007, 1st real-time detection of strand exchange in homologous recombination by RecA; discovery of the small persistence length of ends of microtubules; and solved the system of biosensing with carbon nanotubes
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Experimental section diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
What distinguishes biology from chemistry is the fact that these parts with each other make up a dwelling method. The key of said lifetime, I think, lies from the interactions, the interplay of People molecules. The massive issue about the origin of existence remains unanswered. How did we ever evolve from very simple molecules in to the particularly complicated programs we see now? We have no idea. I would like to operate on These types of large, open up issues.’
Finding out DNA loop extrusion by SMC proteins for chromosome architecture with one-molecule assays.
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Bulk-area coupling identifies the mechanistic connection in between Min-protein patterns in vivo and in vitro
‘The idea that There exists this kind of detail as being a beginning, a huge bang, is by now a fascinating signpost to consider that there was a creator. But much more normally, and on The idea of pure rationality, I also get there in a Christian interpretation of fact. An atheistic worldview is often a naturalistic worldview: essentially, there are actually only atoms and natural forces that we are able to measure.
2006, to start with demonstration of molecular sorting inside a lab over a chip working with biomotors; discovery of nanobubbles in solid-state nanopores; and very first estimate of electrokinetic Electricity conversion in a nanofluidic channel
Visualization of unstained DNA nanostructures with Sophisticated in-target transmission electron microscopy tactics
The biophysicist from Delft – who has become The most cited researchers inside the Netherlands For several years – usually takes his accountability to lead towards the explanation and popularisation of his work on the border of physics and biology very seriously and on a regular basis appears while in the media; Otherwise to discuss his work, then about the connection among science and his Christian religion.